Bibliographic
In this study the authors tested the efficacy of the combined treatment of an adenovirus DNA vaccine, AdPEDI-(Aβ1-6)11, with simvastatin on immune funtion and behavior in young C57BL/6 mice. The results showed that simvastatin significantly increased the number of the mice responding to vaccination compared with the mice receiving only AdPEDI-(Aβ1-6)11. Immunoglobulin isotyping revealed that the vaccination predominantly induced Th2 immune responses. Simvastatin treatment prevented Aβ-induced production of IFN-γ in splenocytes. AdPEDI-(Aβ1-6)11 treatment altered mouse behavior in T- and elevated plus-maze tests and simvastatin counteracted such behavioral changes. These results indicate that simvastatin clearly enhances the immune responses of C57BL/6 mice to the nasal vaccination with AdPEDI-(Aβ1-6)11. Simvastatin may be effective in preventing behavioral changes associated with vaccination.