Resources
Best Practices for Reporting Preclinical Studies
Accelerating Biomedical Discoveries through Rigor and Transparency - NIH proposes to enhance reproducibility throught rigor and transparency.
Literature Supporting Reproducibility – Articles supporting the need for transparency, reproducibility, and translation in preclinical efficacy
ARRIVE Guidelines – Intended to improve the reporting of research using animals
Center for Open Science, Transparency and Openness Promotion (TOP) Guidelines - Published in Science in 2015, TOP includes eight modular standards, each with three levels of increasing stringency
Cost of Reproducibility - View on ways early-career researchers can adopt practices to improve reproducibility while achieving career goals and providing better science.
Experimental Design Assistant - Helps researchers improve the design of animal experiments.
Nature Editorial: Journals Unite for Reproducibility – Consensus on reporting principles
NIH Grants: Policy & Compliance - Resources for Preparing Your Application - Demonstrate rigor in your application by using tools such as the experiemental design assistant, sample size and authentication guides.
- Ways to calculate sample size for your study.
- Knowing what exactly goes into a good authentication plan.
- Assistance with your pre-clinical animal model experimental design
- Guidance on incorporating both sexes into your research plan
NIH Principles and Guideline for Reporting Preclinical Research – Consensus on reporting principles
Rigor or mortis: best practices for preclinical research in neuroscience - Implications of best practices
Animal Models
AlzForum – Research Models – Information about mouse models of Alzheimer’s disease, Amyotrophic Lateral Sclerosis, and related neurodegenerative diseases
Alzheimer's Disease Mouse Model Resource - Jackson Laboratory Repository
Charles River Alzheimer’s Disease Model - CVN and Tg2576 mouse models
MODEL-AD - Model Organism Development and Evaluation for Late-Onset Alzheimer’s Disease
MouseBytes - Open access database for mouse cognition, imaging and genomics data integration
Mouse Genome Informatics - Resource for laboratory mouse, providing integrated genetic, genomic, and biological data
Mouse Models of Alzheimer's Disease - List of Mouse Genome Database Models, The Jackson Laboratory
Search for JAX® Mice - Targeted mutation strains
The Jackson Laboratory: Mouse Phenome Database - Collection of measured data on laboratory mouse strains and populations
Therapeutic Agents & Targets
AMP-AD Target Discovery and Preclinical Validation Project - Integrates data from human brain samples with network modeling approaches and experimental validation for rapid sharing of data
STOP-AD - Offers preclinical screening of compounds through the MODEL-AD Preclinical Testing Core (Slide Deck)
AlzForum Therapeutics - Catalog of the therapeutics currently or previously tested as treatment for Alzheimer's disease and related disorders
Open Targets - Information on the relationships between potential drug targets and diseases, using various data types, showing workflows, and related information on the target or disease
Pharos Targets - Data on protein targets, small molecule activity, genomic behavior and disease links from the University of New Mexico, School of Medicine, Target Central Resource Database
Biomarkers
ADNI | Alzheimer's Disease Neuroimaging Initiative - Unites researchers with study data as they work to define the progression of Alzheimer’s disease
Alzheimer's Biomarkers in Down Syndrome - Initiative to track dementia onset, and progress within Down synrome volunteers
Connectivity Map (also known as cmap) - a collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules and simple pattern-matching algorithms that together enable the discovery of functional connections between drugs, genes and diseases
NIH/NIA/Accelerating Medicines Partnership – Biomarkers Project - Consortium of three NIA-supported Phase II/III secondary prevention trials testing several anti-amyloid therapies
Patents
Espacenet – Contains data on more than 90 million patent documents
Free Patents Online – Patent information including Drugs
Google Patents – Full text of patents from around the world
The Lens – Patents that cite specific authors in the scientific literature
United States Patent and Trademark Office – Department of Commerce, database of patents, patent applications, and other patent documents
Medicinal Chemistry & Pharmacology
ChEMBL - Open large-scale bioactivity database, which offers tracking of compounds in various stages, via the European Bioinformatics Institute
ChemSpider - A database of chemicals owned by the Royal Society of Chemistry
Drug Bank – A bioinformatics and cheminformatics resource that combines detailed drug data with comprehensive drug target information
Open PHACTS Explorer - Answers critical pharmacology questions defined by eight major pharmaceutical companies
PubChem Compound – Contains validated chemical depiction information provided to describe substances
Clinical Trials
Alzheimer’s Disease Clinical Trials from Center Watch - A listing of Alzheimer's Disease medical research trials actively recruiting patient volunteers
Alzheimer’s Disease Cooperative Study (ADCS) - Develops and tests new interventions and treatments for Alzheimer’s disease that might not otherwise be developed by industry
ClinicalTrials.gov - Clinical studies on a wide range of diseases and conditions
Webinar Transcript: Draft Guidance For Industry On Alzheimer’s Disease: Developing Drugs For The Treatment Of Early Stage Disease – Transcript for FDA Webinar
Data Resources & Data Repositories
Academic Drug Discovery Consortium – Central repository of drug discovery centers, partnerships, job opportunities and events
ADNI | Alzheimer's Disease Neuroimaging Initiative - Unites researchers with study data as they work to define the progression of Alzheimer’s disease
ALZGENE – Field synopsis of genetic association studies in AD
Agora - Discover Alzheimer's Disease Genes - (BETA) Designed to aggregate evidence in support of AD target discovery
Alzheimer's Disease Genetics Consortium (ADGC) – Research to identify genes associated with an increased risk of developing late-onset Alzheimer’s disease
Alzheimer’s Disease Sequencing Project (ADSP) - Large scale sequencing project to identify AD risk and protective gene variants
AMP-AD Knowledge Portal - Accelerating Medicine Partnership for Alzheimer's Disease Target Discovery and Preclinical Validation Project
Comparative Toxicogenomics Database - Database that aims to advance understanding about how environmental exposures affect human health
Gene Ontology Consortium - Computational model of biological systems, from the molecular level to larger pathways, cellular and organism-level systems
KEGG Pathway Database - Wiring diagrams of molecular interactions, reactions, and relations
International Alzheimer’s Disease Research Portfolio (IADRP) - Brings together funded research supported by public and private organizations both in the US and abroad
National Cell Repository for Alzheimer’s Disease – Helps researchers find genes that increase the risk for Alzheimer’s disease (AD) and dementia
PhenX Toolkit - Catalog of recommended, standard measures of phenotypes and environmental exposures for use in biomedical research
The NIA Genetics of Alzheimer’s Disease Data Storage (NIAGADS) Site - Data from genomic studies of late-onset Alzheimer’s disease, available to qualified investigators
The National Alzheimer's Coordinating Center – A large relational database of standardized clinical and neuropathological research data
Literature Indexes
PubMed – Citations to life science and biomedical literature
EMBASE [Subscription needed] – Biomedical literature database
FDA Resources on Drugs and Devices – Resources on drugs and devices
Text Mining Resources
OntoMate – A text mining tool aiding curation at the Rat Genome Database
PhenoMiner – Text-data mining of phenotype relations from biomedical literatures
PubTator - Web-based tool for accelerating manual literature curation