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Outcome Parameters List

Each Outcome Parameter falls within one or more Outcomes Measures. Choose the best Outcome Measure for a parameter from the drop down menu below, and view the Parameter options that fall within that Outcome Measure. If you do not see a Parameter that adequately describes your outcome, you may add your own terms within the SUBMIT YOUR DATA/OUTCOMES data entry form.
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Pharmacodynamics

  • Target Engagement (Inhibition GABA-A Receptor)
  • Target Engagement (Inhibition Glutaminyl Cyclase)
  • Target Engagement (Inhibition Glycogen Synthase)
  • Target Engagement (Inhibition Histone Deacetylases)
  • Target Engagement (Inhibition Insulin-Like Growth Factor 1 Receptor)
  • Target Engagement (Inhibition Mechanistic Target of Rapamycin)
  • Target Engagement (Inhibition Mitochondrial Respiratory Complex I)
  • Target Engagement (Inhibition Neutral Sphingomyelinase 2)
  • Target Engagement (Inhibition p38 alpha Mitogen-Activated Protein Kinase)
  • Target Engagement (Inhibition Protein Kinase A)
  • Target Engagement (Inhibition S100 Calcium-Binding Protein B Expression)
  • Target Engagement (Inhibition Spectrin Cleavage)
  • Target Engagement (Inhibition Tubulin Deacetylation)
  • Target Engagement (Inhibition Tumor Necrosis Factor alpha Gene Expression)
  • Target Engagement (Knockdown alpha-1 Adrenergic Receptor)
  • Target Engagement (Knockdown BACE1)
  • Target Engagement (Knockdown Caspase 1)
  • Target Engagement (Knockdown DDIT4/REDD1/RTP801)
  • Target Engagement (Knockdown IDOL)
  • Target Engagement (Knockdown NLRP1)
  • Target Engagement (Knockdown NLRP3)
  • Target Engagement (Knockdown Presenilin 1)
  • Target Engagement (Reduction Acetylated-ATG9A (Ac-ATG9A))
  • Target Engagement (Reduction Active Glycogen Synthase Kinase beta-Brain)
  • Target Engagement (Reduction Adenosine A2A Receptor)
  • Target Engagement (Reduction alpha Synuclein)
  • Target Engagement (Reduction Amyloid Load)
  • Target Engagement (Reduction Amyloid Precursor Protein-Brain)
  • Target Engagement (Reduction Apolipoprotein E)
  • Target Engagement (Reduction beta Amyloid Deposits)
  • Target Engagement (Reduction beta Amyloid Oligomers)
  • Target Engagement (Reduction beta Amyloid Peptide 38-Brain)
  • Target Engagement (Reduction beta Amyloid Peptide 38-Plasma)
  • Target Engagement (Reduction beta Amyloid Peptide 40-Brain)
  • Target Engagement (Reduction beta Amyloid Peptide 40-CSF)
  • Target Engagement (Reduction beta Amyloid Peptide 40-Plasma)
  • Target Engagement (Reduction beta Amyloid Peptide 42-Brain)
  • Target Engagement (Reduction beta Amyloid Peptide 42-CSF)
  • Target Engagement (Reduction beta Amyloid Peptide 42-Plasma)
  • Target Engagement (Reduction beta Amyloid Peptide 42-Serum)
  • Target Engagement (Reduction beta Amyloid Peptides-Brain)
  • Target Engagement (Reduction beta Amyloid Peptides-CSF)
  • Target Engagement (Reduction beta Amyloid Peptides-ISF)
  • Target Engagement (Reduction beta Amyloid Peptides-Plasma)
  • Target Engagement (Reduction beta Amyloid Peptides-Serum)
  • Target Engagement (Reduction Blood Pressure)
  • Target Engagement (Reduction Calpain Activity)
  • Target Engagement (Reduction Cholesteryl Ester-Brain)
  • Target Engagement (Reduction Complement C5a-Plasma)
  • Target Engagement (Reduction Copper Level-Brain)
  • Target Engagement (Reduction Corticosterone Level-Plasma)
  • Target Engagement (Reduction Dickkopf-Related Protein 1)
  • Target Engagement (Reduction Dynamin-1-Like Protein)
  • Target Engagement (Reduction Eicosanoid Production)
  • Target Engagement (Reduction Eukaryotic Elongation Factor 2 Phosphorylation)
  • Target Engagement (Reduction Glucose Concentration-Blood)
  • Target Engagement (Reduction Glycogen Synthase Kinase 3 beta-Brain)
  • Target Engagement (Reduction Interleukin 1 beta)
  • Target Engagement (Reduction Lipid Peroxidation-Brain)
  • Target Engagement (Reduction Luteinizing Hormone Level-Serum)
  • Target Engagement (Reduction Metals)
  • Target Engagement (Reduction Mitochondrial TDP-43)
  • Target Engagement (Reduction N3pE-beta Amyloid-Brain)
  • Target Engagement (Reduction pGlu-3 beta Amyloid-Brain)
  • Target Engagement (Reduction phospho-alpha Synuclein)
  • Target Engagement (Reduction phospho-Tau)
  • Target Engagement (Reduction Prostaglandin E2)
  • Target Engagement (Reduction Soluble Amyloid Precursor Protein alpha)
  • Target Engagement (Reduction Soluble Amyloid Precursor Protein beta)
  • Target Engagement (Reduction Tau-CSF)
  • Target Engagement (Reduction Tau)
  • Target Engagement (Reduction Total Cholesterol-Plasma)
  • Target Engagement (Reduction Total Cholesterol-Serum)
  • Target Engagement (Reduction Tumor Necrosis Factor alpha-Plasma)
  • Target Engagement (Reduction Tumor Necrosis Factor Superfamily Member 10)
  • Target Engagement (Reduction Voltage Dependent Anion Channel 1 Oligomerization)
  • Target Engagement (Restore Filamin A Native Conformation)

Pharmacokinetics

  • Antibody Concentration-Blood
  • Antibody Concentration-Brain
  • Antibody Concentration-CSF
  • Antibody Concentration-ISF
  • Antibody Concentration-Plasma
  • Antibody Concentration-Serum
  • Antibody Distribution-Brain
  • Area Under the Curve (AUC)
  • ASN12 Concentration-Blood
  • BDNF Concentration-Brain
  • Bioavailability
  • Biodistribution/Persistence Analysis
  • Blood Brain Barrier Penetration
  • Blood t1/2
  • Brain Efflux Index (BEI)
  • Brain t1/2
  • Brain/CSF Ratio
  • Brain/Plasma Ratio
  • Brain/Serum Ratio
  • Capillary Depletion
  • Clearance (L/h/kg)
  • Cmax
  • CSF/Plasma Ratio