Bibliographic
This study investigated effects of resveratrol on neuroprotection, longevity, cognitive impairment, and neuropathology in SAMP8 mice. Resveratrol, a naturally occurring polyphenol mainly found in grapes and red wine, has been reported as a caloric restriction (CR) mimetic with potential anti-aging and antidiabetogenic properties. The most widely accepted mechanistic hypothesis is that resveratrol’s effects, in the same way as CR, are driven through Sirtuin 1 (SIRT1) regulation. It is widely accepted that resveratrol benefits are mediated through AMPK activation. Thus, resveratrol leads to increases in the NAD-to-NADH cell ratio, which results in activation of AMPK in vivo, initiating a signaling process that regulates insulin sensitivity and recruits mediators of oxidative metabolism and mitochondrial biogenesis. Several in vitro and in vivo studies also support the hypothesis that resveratrol may be a powerful agent in preventing age-associated neurodegeneration, such as lowering Aβ levels and improving cognitive deficits. This study used age-accelerated mice (SAMP8) that has age-related neuropathological changes like Aβ aggregation and tau hyperphosphorylation. Results show that resveratrol increased mean life expectancy and maximal life span, activates AMPK pathways and pro-survival routes such as SIRT1, reduces cognitive impairment,decreases amyloid burden, and reduces tau hyperphosphorylation.