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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease


Year of Publication:
Contact PI Name:
David Morgan
Contact PI Affiliation:
Department of Pharmacology, Alzheimer Research Laboratory, University of South Florida, Tampa, Florida USA
David M. Diamond, Paul E. Gottschall, Kenneth E. Ugen, Chad Dickey, John Hardy, Karen Duff, Paul Jantzen, Giovanni DiCarlo, Donna Wilcock, Karen Connor, Jaime Hatcher, Caroline Hope, Marcia Gordon, Gary W. Arendash
Primary Reference (PubMED ID):
Funding Source:
Benjamin Research Trust
University of South Florida Research Foundation
National Institute on Aging (NIA)
National Heart Lung and Blood Institute (NHLBI)
National Institute of Allergy and Infectious Disease (NIAID)
Study Goal and Principal Findings:

In this study the authors showed that vaccination with Abeta peptide 42 protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease. The Abeta-vaccinated mice also had a partial reduction in the beta amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly treat Alzheimer's dementia.

Bibliographic Notes:
Erratum in: Nature 2001 Aug 9;412(6847):660.

Therapeutic Agent

Therapeutic Information:
Therapy Type:
Biologic - Immunotherapy(active)
Therapeutic Agent:
beta Amyloid Peptide
Therapeutic Target:
beta Amyloid Peptide

Animal Model

Model Information:
Model Type:
Strain/Genetic Background:
Mixed Background of C57B6/SJL and Swiss Webster/B6D2F1

Experimental Design

Is the following information reported in the study?:
Power/Sample Size Calculation
Randomized into Groups
Blinded for Treatment
Blinded for Outcome Measures
Pharmacokinetic Measures
Pharmacodynamic Measures
Toxicology Measures
ADME Measures
Route of Delivery
Duration of Treatment
Frequency of Administration
Age of Animal at the Beginning of Treatment
Age of Animal at the End of Treatment
Sex as a Biological Variable
Study Balanced for Sex as a Biological Variable
Number of Premature Deaths
Number of Excluded Animals
Statistical Plan
Genetic Background
Inclusion/Exclusion Criteria Included
Conflict of Interest


Outcome Measured
Outcome Parameters
Radial Arm Water Maze
beta Amyloid Load
Anti-beta Amyloid Peptide 42 Antibody Titers