Bibliographic
In this study the authors tested the efficacy of the RXR agonists bexarotene (Targretin) in clearance of beta amyloid peptides from brains of AD Tg mouse models. Oral administration of the RXR agonist bexarotene to a mouse model of AD resulted in enhanced clearance of soluble beta amyloid peptide within hours in an apoE-dependent manner, and beta amyloid plaque area was reduced more than 50% within just 72 hours. Furthermore, bexarotene stimulated the rapid reversal of cognitive, social, and olfactory deficits and improved neural circuit function. Thus, RXR activation stimulates physiological beta amyloid clearance mechanisms, resulting in the rapid reversal of a broad range of beta amyloid-induced deficits.