AlzPED can be queried in a variety of ways including a general text search or searching individual fields such as: Title, PI Name, Primary Reference (PubMed ID), Funding Source, Therapy Type, Therapeutic Target, Therapeutic Agent, Model Name and Model Type.
A general text search can be performed from the main “Search” box on the home page or the Full Text Search box found by using the “Search AlzPED” link on the Home page, under the AlzPED banner.
Text queries search the entire textual content of all fields of the database and, links to other databases (e.g., related citations in PubMED, Clinical trials.gov, patents). Using a general text query you can search the database for therapeutic targets (e.g., “beta-secretase”,BACE1, “gamma-secretase”, “HMG-CoA reductase” ), therapeutic agents (e.g., curcumin, simvastatin, bexarotene ), animal models (e.g., Tg2576, 3xTg).
Text term queries are not case sensitive however, text terms/phrases should be placed in quotes, (“”) so the system knows to search for that exact character string. Otherwise the search engine will search for each term in the phrase individually. For example, compare searches with:
“beta secretase” - yielding 13 results vs. beta secretase - yielding 28 results
In the case of the latter the search engine will search for beta OR secretase.
If two terms are entered into a single field the default Boolean operator is OR.
If terms are entered into separate fields the default Boolean operator is AND.
* Note that more accurate search results are likely to be obtained by searching the individual fields as described below.
Individual fields - PI (Principal Investigator) Name, Title, PubMed ID, Funding Source, Therapy Type, Therapeutic Agent, Therapeutic Target, Animal Model Type and Animal Model Name can be searched by selecting either the “Search AlzPED” link under the AlzPED banner, or selecting “More Search Options” directly under the main Search Box on the Home page.
Full Text Search - This search box performs identically as the main Search box on the Home page.
Title - Keywords, phrases, and full-titles can be searched in this field. Place quotes (“”) around key words and phrases, to search for a specific string of characters. Otherwise the system will search for each term within the phrase or title individually, producing a much larger result set. If two terms are entered into a single field the default Boolean operator is OR. If terms are entered into separate fields the default Boolean operator is AND.
Primary Reference (PubMed ID) - Enter the PubMed ID number to find AlzPED information related to articles indexed in Medline PubMed. For published papers, please see the original publication or PubMed.gov to identify the PMID and search by the PMID.
Contact PI/Author Name - Authors can be found by searching either their last name, full name or a variation of those names.
*Note: Only the identified Corresponding Author has been entered into the system; co-authors will not be found.
Funding Source - Funding Organizations can be searched by beginning to type the full name of the funding organization, and then using the drop down menu to select the organization. Multiple organizations can be selected by holding down the Control key.
Therapy Type - Refers to the agent classification based on source (natural product or synthetic), molecular structure (small molecule, biologic), chemical nature (protein, peptide, hormone, RNA, DNA), mechanism of action ( immunotherapy active, immunotherapy passive).These can be queried by clicking in the Therapy Type field and choosing an option. Multiple Therapy Types can be selected by holding down the control key and selecting additional Therapy Types. Alternatively, you can continue searching by typing and selecting other choices from the drop down menu as well.
Therapeutic Target - Refers to the molecular or cellular structure through which an agent mediates its therapeutic activities. AlzPED lists targets alphabetically; these can be searched by clicking in the Therapeutic Target field and choosing one of the target options or just by beginning to type the target name. Multiple targets can be selected by continuing this process until you are ready to execute the search.
Therapeutic Agent - Users can find agent entries by typing the agent name in the Therapeutic Agent field. A query can contain more than one agent name (e.g., Tadalafil, Sildenafil).
Model Name - Refers to the designation given to the animal model by the scientific community. AlzPED houses the names of large number of animal model names including transgenic mice and rats, non-trangenic mice and senescence-accelerated mice. Also housed are names of “wild-type” animals used in therapy development (e.g., aged mice, young and aged Fischer, Wistar, Sprague-Dawley rats, Rhesus and Cynomolgous non-human primates, etc). To search start typing in the Model Name field and options will appear in the drop down menu. Multiple model names can be selected for a single search by selecting multiple options from the drop down menu.
Model Type - Refers to the human gene of homolog associated with neuropathological and clinical phenotypic characteristics of Alzheimer’s disease. Model types can include single or multiple combinations of genes (e.g., APP, ApoE4, APPxPS1, hTau, APPxPS1xhTau, etc). Excluded are animals with genetic manipulations that have limited clinical relevance to AD (e.g., knock-outs of APP, tau, PSEN1 and PSEN2). To query model types start typing in the Model Type field and select options from the drop down menu. Select multiple options by using the control key.
General text or individual field searches will take the user to the Search Results screen. There each record is displayed by AlzPED ID (APID), Title, Year, Contact PI and Therapeutic Agent. To view the data for an individual record click on the title. Records can be sorted by APID, Year or Contact PI. Results can be exported to Excel using either the All Results or Selected Results options at the top of the Search Results screen.