How To Enter Data

AlzPED is designed as a knowledge platform for the housing, sharing and mining of both published and unpublished data relating to the preclinical testing of candidate therapeutic agents in AD animal models. The data housed in AlzPED are gleaned from two sources – 1) the scientific literature and 2) directly from researchers and, submitted through a curator. For direct submission researchers must register their studies on line and submit data directly. In this context data refers to information about a study, not the scientific data collected during the study.  The curator will conduct the initial review and determine if the study is acceptable for incorporation into the database.

To begin entering data first Create an Account.

Once registered AlzPED users can click-on Submit Your Data and upload published or, unpublished data. There are 5 data sections/categories: Bibliographic, Therapeutic, Animal Model, Experimental Design and Outcomes.  For explainations about the fields in each category follow the provided Tool Tips (?).

You may save information within each section (complete or incomplete), to move onto the next section.  You can return to the previous sections any time before you upload the data to AlzPED.

To assist with data entry please follow the tool tips (?) provided in each section.

If you have questions please Contact Us.

BILIOGRAPHIC
  • Unpublished/Published - Has the study been published (e.g., journal or monograph), or is it the study unpublished? 
  • Title of the Study - List the full title of the article or report.
  • Contact Author Last Name - Select the person who is the primary point of contact (corresponding or senior author) for the research article/report.
  • Contact Author First Name - If the author (primary point of contact) formally goes by a middle name, an initial can be listed here.
  • Contact Author Middle Initial - If the author uses their middle name, a full name can be inserted here.
  • Contact Author Affiliation - List the Department, School, Institution, City, Region/State, Country for the Contact Author.
  • Primary Reference (PubMed ID) - For published articles this is the PubMed ID.  You can leave this field blank and it will be completed by the AlzPED Curator.
  • Funding Source - List funding sources that supported the study.  You can select one or more Funding Sources from the drop down menu, or enter the Funding Source if it does not appear within the list.
  • Study Goal and Principal Findings - Enter the primary study goal(s), and the overall outcomes anticipated/found, and information learned from the study.  
  • Bibliographic Notes - Include any unique features regarding the citation or bibliographic information. For example, this space can be used to include co-authors/co-investigators.

Save this section and move to the next section.

THERAPEUTIC AGENT
  • Therapeutic Agent - Enter the name of the Therapeutic Agent being tested for a disease-relevant therapeutic activity.  If more than one agent is used, use the Add More button to add additional agents.
  • Therapy Type - Enter the type of agent based on source (natural product or synthetic), molecular structure (small molecule, biologic), chemical nature (protein, peptide, hormone, RNA, DNA), mechanism of action, (immunotherapy active, immunotherapy passive). See the drop down list.
  • Therapeutic Target - Enter the molecular or cellular structure through which an agent mediates its therapeutic activities. See the drop down list.  If your target in not on the list, enter the term to add it as a target.
  • Links to PubMED, PubChem, Drugbank, Clinical Trials, Patents - These fields will be completed by the AlzPED curator.  If you have suggestions for sources to use for these links, please provide them in the Therapeutic Notes field.
  • Therapeutic Notes - Include any additional information or unique features regarding the therapeutic agent used in the study.

Save this section and move to the next section.

ANIMAL MODEL
  • Species - Enter the species of animal(s) used in the study (e.g., mouse, rat, non-human primate).  See the drop down list.  If it does not appear enter the species. If more than one species is used, use the Add More button to add additional animal models.
  • Model Type - Refers to the human gene or homolog that is believed to be causative or contributing to neuropathological and clinical phenotypes associated with Alzheimer’s disease. For example APP, APPxPSEN, ApoE4, APPx ApoE4, hTau, APPxPSEN1xhTau. Excluded are animals with genetic manipulations that have limited clinical relevance to AD (e.g., knock outs of APP,  tau, PSEN 1 or PSEN2).  If more than one model type is used, use the Add More button, to add additional animal models.
  • Model Name - Refers to the designation given to the model by the scientific community (e.g.; Tg2576, 5xFAD, 3xTg, J20). In some cases this designation identifies a specific gene/mutation pairing associated with AD phenotypes (e.g., APPSwePSEN1d9). If more than one model is used, use the Add More button to add additional animal models. 
  • Strain/Genetic Background - Refers to the strain (genetic background) of the animal model upon which the human AD gene or homolog resides (e.g., [C57BL/6 x C3H]F2).
  • Aged Model - Refers to the use of an animal models that have aged and developed disease characteristics naturally (20 months), as opposed to animals that have been breed to develop certain aspects of disease at an earlier age (2 months) in their life cycle.  Aged models are thought to provide better relative data, and thus better translatable data.
  • Animal Model Notes - Include any additional information or unique features regarding the animal model used in the study.

Save this section and move to the next section.

EXPERIMENTAL DESIGN

Please indicate whether your study includes the experimental design elements listed on the page by placing a check in the box next to each element that can be identified within your study.  Please review the experiment report critically to ensure that someone reviewing the report would be able to make those correlations.  See the Tool Tips (?) for clarification of terms and definitions.

  • Power/Sample Size Calculation
  • Randomized into Groups
  • Blinded for Treatment
  • Blinded for Outcome Measures
  • Pharmacokinetic Measures
  • Pharmacodynamic Measures
  • Toxicology Measures
  • ADME Measures
  • Use of Biomarkers
  • Dose
  • Formulation
  • Route of Administration
  • Frequency of Administration
  • Duration of Treatment
  • Age of Animal at the Beginning of Treatment
  • Gender
  • Balanced for Gender
  • Number of Premature Deaths
  • Number of Excluded Animals
  • Statistical Plan
  • Conflict of Interest
  • Experimental Design Notes – Include any additional information relevant to the Experimental Design of the study. For example, use this field to list articles that report data relevant to the listed experimental design elements.

Save this section and move to the next section.

OUTCOMES

Enter each Outcome Measure used in the study and enter the corresponding Outcome Parameters associated with the outcome measure.  Outcome Measures should appear in the order listed below.  Please see the Outcomes Parameters drop down menu for existing options that best describe the experiment parameters.  If you have used an Outcome Parameter which is not listed in the drop down menu, enter your own parameter in the appropriate text box.

Outcome Measures                                                       

  • Behavioral          
  • Motor Function
  • Histopathology  
  • Biochemical
  • Immunochemistry
  • Microscopy
  • Electron Microscopy
  • Imaging
  • Cell Biology
  • Immunology
  • Biomarkers
  • Electrophysiology
  • Pharmacokinetics
  • Pharmacodynamics
  • Toxicology
  • Pharmacology
  • OMICS

Outcome Notes : Include any additional information relevant to the Outcomes reported in the study.

Save this section.

REVIEW AND SUBMIT

Review all of your data for completeness and accuracy.  Once you submit your data, you cannot make changes until the curator has reviewed the citation.  The curator will contact you with any questions or concerns, prior to adding the citation to the AlzPED database. Contact Us if you have any questions.