Bibliographic
Antabine is a minor tobacco alkaloid which is present in plants of the Solanacea family including tobacco, green tomatoes, peppers and eggplants. In the present study the authors investigated the effects of anatabine on Aβ production in vitro and in vivo in a transgenic mouse model of Alzheimer's disease. Data show that anatabine inhibits NFκB activation, inhibits BACE-1 transcription and reduces BACE-1 protein levels, and significantly lowers brain soluble Aβ1–40 and Aβ1–42 levels in a transgenic mouse model of Alzheimer's disease. The data suggest that anatabine may be a useful compound for regulating brain Aβ accumulation.