AlzPED Study Inclusion Methods

Sources for Studies

AlzPED is intended to include efficacy studies from published and unpublished reports.  Published studies for AlzPED have been gleaned from databases including: Medline PubMed, EMBASE, ISI Web of Science, and SCOPUS.  Certain journal publications are also reviewed for preclinical studies that may not necessarily appear in the indexes listed.  Some of the titles for these publications are listed below:

Journal Publications Searched for AD Preclinical Efficacy Studies

  • Advances in Alzheimer's Disease 
  • Alzheimer Disease and Associated Disorders   
  • Alzheimer's and Dementia   
  • Alzheimer's Research and Therapy   
  • American Journal of Alzheimer's Disease   
  • Animal Cognition
  • Applied Animal Behaviour Science  
  • Cognitive Neuroscience 
  • Current Alzheimer Research   
  • International Journal of Alzheimer's Disease  
  • JAALAS (formerly Contemporary Topics in Laboratory Animal Science)   
  • Journal of Alzheimer's Disease   
  • Journal of Neural
  • Transmission – Parkinson’s Disease and Dementia Section   
  • Learning & Behavior
  • Neurobiology of Disease & Regeneration
  • Neuropharmacology & Psychopharmacology
 

Characteristics of Studies Selected for Inclusion

All of the published studies selected for this database must:

  • Be written in English
  • Have been published between 1995 and the present
  • Test one or more therapeutic agents (excluding those that are non-pharmacological; e.g., exercise, environmental enrichment, diet, genetic etc.)

    • Test therapeutic agents in:  APP, Tau and  Presenlin- based transgenic rodent models;  rodent models based on beta amyloid injection; aged rodent models;  senescence accelerated rodent models; aged canine models, non- human primate models. Genetic manipulations such as knock-outs of APP, Presenilin, Tau, ApoE, etc, are not included since they have no relevance to clinical Alzheimer’s disease.
    • Evaluate efficacy of treatment on the Alzheimer's disease phenotype exhibited by at least one of the above listed models
    • Provide methods, results, outcomes, and conclusions from the study

Terms/Concepts Used for Identifying the Literature

Search terms and concepts for the databases and journals mentioned above are intended to capture an inclusive result set as possible, while still producing a successful result set.   Three concepts have been included in the search strategies:

Search Concept A: Alzheimer’s, Alzheimer’s disease, Tau, Beta Amyloid Plaque, Cognitive Memory Impairment, and Dementia

Search Concept B: Animal Model, Mouse, Mice, Rodent, Rat, Canine, Dog, Chimpanzee, Chimp, and Non-human primate

Search Concept C: Therapy, Therapeutics, Treatment, Efficacy, Efficacious, and Drug development