AlzPED Study Inclusion Methods

Sources for Studies

AlzPED is intended to include efficacy studies from published and unpublished reports.  Published studies for AlzPED have been gleaned from databases including: Medline PubMed, EMBASE, ISI Web of Science, and SCOPUS. 

Characteristics of Studies Selected for Inclusion

All of the published studies selected for this database must:

  • Be written in English
  • Have been published between 1995 and the present
  • Test one or more therapeutic agents (excluding those that are non-pharmacological; e.g., exercise, environmental enrichment, diet, genetic etc.)

    • Test therapeutic agents in:  APP, Tau and  Presenlin- based transgenic rodent models;  rodent models based on beta amyloid injection; aged rodent models;  senescence accelerated rodent models; aged canine models, non- human primate models. Genetic manipulations such as knock-outs of APP, Presenilin, Tau, ApoE, etc, are not included since they have no relevance to clinical Alzheimer’s disease.
    • Evaluate efficacy of treatment on the Alzheimer's disease phenotype exhibited by at least one of the above listed models
    • Provide methods, results, outcomes, and conclusions from the study

Terms/Concepts Used for Identifying the Literature

Search terms and concepts for the databases and journals mentioned above are intended to capture an inclusive result set as possible, while still producing a successful result set.   Three concepts have been included in the search strategies:

Search Concept A: Alzheimer’s, Alzheimer’s disease, Tau, Beta Amyloid Plaque, Cognitive Memory Impairment, and Dementia

Search Concept B: Animal Model, Mouse, Mice, Rodent, Rat, Canine, Dog, Chimpanzee, Chimp, and Non-human primate

Search Concept C: Therapy, Therapeutics, Treatment, Efficacy, Efficacious, and Drug development