AlzPED Study Inclusion Methods
AlzPED is intended to include efficacy studies from published and unpublished reports. Published studies for AlzPED have been gleaned from databases including: Medline PubMed, EMBASE, ISI Web of Science, and SCOPUS.
All of the published studies selected for this database must:
- Be written in English
- Have been published between 1995 and the present
- Test one or more therapeutic agents (excluding those that are non-pharmacological; e.g., exercise, environmental enrichment, diet, genetic etc.)
- Test therapeutic agents in: APP, Tau and Presenlin- based transgenic rodent models; rodent models based on beta amyloid injection; aged rodent models; senescence accelerated rodent models; aged canine models, non- human primate models. Genetic manipulations such as knock-outs of APP, Presenilin, Tau, ApoE, etc, are not included since they have no relevance to clinical Alzheimer’s disease.
- Evaluate efficacy of treatment on the Alzheimer's disease phenotype exhibited by at least one of the above listed models
- Provide methods, results, outcomes, and conclusions from the study
Search terms and concepts for the databases and journals mentioned above are intended to capture an inclusive result set as possible, while still producing a successful result set. Three concepts have been included in the search strategies:
Search Concept A: Alzheimer’s, Alzheimer’s disease, Tau, Beta Amyloid Plaque, Cognitive Memory Impairment, and Dementia
Search Concept B: Animal Model, Mouse, Mice, Rodent, Rat, Canine, Dog, Chimpanzee, Chimp, and Non-human primate
Search Concept C: Therapy, Therapeutics, Treatment, Efficacy, Efficacious, and Drug development